EFFICACY AND SAFETY OF INTRAVENOUS PARACETAMOL VERSUS INDOMETHACIN FOR CLOSURE OF HEMODYNAMICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN PRETERM NEONATES

Hemodynamically significant patent ductus arteriosus (hs-PDA) is a common cause of morbidity and mortality among preterm infants, affecting more than 40% infants. A persistent hs-PDA can problems, especially in premature Thus, the early closure important to prevent several comorbidities such as necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), pulmonary edema/hemorrhage, development chronic lung disease (CLD).